Acetic Acid → Benzhydrol

HRID 217549

반응식

HRID 217549 반응식
[C:1]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH4+].[Cl-].CC(O)=O>C1COCC1>[C:9]1([CH:1]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[OH:8])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 3102BenzophenoneHCID 25517Ammonium Chloride

생성물 1

HCID 7037Benzhydrol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1 mmole (182 mg) of benzophenone dissolved in 5 mL THF was stirred with 0.5 g of 12% Li-AG and solid state proton sources such as NH4Cl, (NH4)2HPO4, or dropwise addition of glacial AcOH at room temperature after a deep blue colored solution is produced. The color of the reaction vessel gradually fades and becomes grey at the end indicating complete consumption of lithium. The reaction mixture was filtered, the solids washed with hexane, and the solvent was removed from the combined organic solutions under vacuum to obtain a white solid corresponding to diphenyl methanol as confirmed by 1H, 13C NMR and ESI-MS. See FIGS. 3A-3C.

후처리

  1. customis produced
  2. customconsumption of lithium
  3. filtrationThe reaction mixture was filtered
  4. washthe solids washed with hexane
  5. customthe solvent was removed from the combined organic solutions under vacuum

출처 및 근거

ORD 기록
ord-fec6cb85a6e2434088d9a39ed31a0e85
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08197707B2

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