Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroform methanol → 2-(2-{2-[2-(2,2-Dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroform methanol | HCID 21584188 | — |
| 반응물 | Sodium hydroxide methanol | HCID 23721981 | — |
| 반응물 | Acetic acid 2-(2-{2-[2-(2,2-dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester | HCID 59236850 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-(2-{2-[2-(2,2-Dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol | HCID 59236859 | 76% |
반응 단계
1 N NaOH/Methanol (1 ml) was added to a stirring solution of acetic acid 2-(2-{2-[2-(2,2-dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester (Compound 4) (110 mg, 0.34 mmol) in methanol (3 ml) at ambient temperature. The reaction was monitored by TLC (CHCl3/MeOH, 9:1) and was completed within 30 minutes. The solvent was evaporated and the residue purified by flash chromatography (CHCl3/MeOH, 9:1) to afford the product (73 mg, 76%) as a colourless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08197793B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-a6236d5da9ea486d949e7dc156ab0ff8 |
| 출처 메모 | uspto-grants-2012_06 |