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Ethyl Acetate → 2-(2-{2-[2-(2-Fluoro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-1,1-dimethoxy-ethane

HRID 217553
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인쇄 미리보기

반응식

HRID 217553 반응식
[CH3:1][O:2][CH:3]([O:22][CH3:23])[CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH2:15][CH2:16]OS(C)(=O)=O.CCCC[N+](CCCC)(CCCC)CCCC.[F-:41].C(OCC)(=O)C>C(#N)C>[F:41][CH2:16][CH2:15][O:14][CH2:13][CH2:12][O:11][CH2:10][CH2:9][O:8][CH2:7][CH2:6][O:5][CH2:4][CH:3]([O:22][CH3:23])[O:2][CH3:1]
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참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 2724141Tetrabutylammonium FluorideHCID 59236870Methanesulfonic acid 2-(2-{2-[2-(2,2-dimethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester

생성물 1

HCID 592368632-(2-{2-[2-(2-Fluoro-ethoxy)-ethoxy]-ethoxy}-ethoxy)-1,1-dimethoxy-ethane수율 93%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
90 °C

실험 절차

A mixture of the sulfonate (Compound 6) (75 mg, 0.21 mmol) and TBAF (1.1 M in THF, 573 μl, 0.63 mmol) in acetonitrile (8 ml) was heated at 90° C. for 30 minutes. TLC (ethyl acetate) monitoring showed the reaction was completed. After cooling to ambient and evaporation of the solvent the residue was flashed (Ethyl acetate) to afford the product (56 mg, 93%) as colourless oil.

후처리

  1. temperatureAfter cooling to ambient and
  2. customevaporation of the solvent the residue

출처 및 근거

ORD 기록
ord-2ddeb037ade64fdc9a47cb1ebdf2557e
출처 데이터셋
uspto-grants-2012_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08197793B2

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