Water → 4-(3-Fluoropropoxy)benzaldehyde

HRID 217554

반응식

HRID 217554 반응식
[F-:1].[K+].C1N2CCOCCOCCN(CCOCCOCC2)CCOCCOC1.[CH:29]([C:31]1[CH:45]=[CH:44][C:34]([O:35][CH2:36][CH2:37][CH2:38]OS(C)(=O)=O)=[CH:33][CH:32]=1)=[O:30].O>C(#N)C>[F:1][CH2:38][CH2:37][CH2:36][O:35][C:34]1[CH:44]=[CH:45][C:31]([CH:29]=[O:30])=[CH:32][CH:33]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 728012,2,2-CryptandHCID 522689Potassium FluorideHCID 59236855Methanesulfonic acid 3-(4-formylphenoxy)propyl ester

생성물 1

HCID 27829714-(3-Fluoropropoxy)benzaldehyde

시약·촉매·용매 1

HCID 6342Acetonitrile용매3회

반응 조건

온도
60 °C

실험 절차

Potassium fluoride (Fluka, 7.2 mg, 0.124 mmol) and kryptofix 222 (Fluka, 46.7 mg, 0.124 mmol) were dissolved in dry acetonitrile (2.5 ml). After 10 min the mixture was added to a stirred solution of methanesulfonic acid 3-(4-formylphenoxy)propyl ester 13 (16.0 mg, 0.062 mmol) in dry acetonitrile (1.5 ml). The reaction mixture was heated at 60° C. for 30 minutes. The product was confirmed by analytical HPLC (column Phenomenex Luna C18(2) 3 μm 4.6×50 mm, solvents: A=water/0.1% TFA and B=acetonitrile/0.1% TFA; gradient 10-80% B over 10 min; flow 2.0 ml/min, UV detection at 214 and 254 nm) co-eluting with commercial standard (Fluorochem) at 5.0 minutes.

후처리

  1. customat 5.0 minutes

출처 및 근거

ORD 기록
ord-6799a10eada64d6688f75700a3445624
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08197793B2

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