1,3-Difluoroacetone → HCID 86706177, 화합물
반응식
[CH2:1]([O:3][C:4](=[O:12])[C:5]([CH2:10][OH:11])([CH2:8][OH:9])[CH:6]=[CH2:7])[CH3:2].[F:13][CH2:14][C:15]([CH2:17][F:18])=O>>[CH2:1]([O:3][C:4]([C:5]1([CH:6]=[CH2:7])[CH2:8][O:9][C:15]([CH2:17][F:18])([CH2:14][F:13])[O:11][CH2:10]1)=[O:12])[CH3:2]참가 물질
3
반응 조건
- 온도
- 100 °C
실험 절차
A vial was loaded with 2,2-bis-hydroxymethyl-but-3-enoic acid ethyl ester (0.88 g, 5.05 mmol), 1,3-difluoroacetone (0.95 g, 10.1 mmol) and para-toluene-4-sulfonic acid monohydrate (0.96 g, 5.05 mmol). The vial was sealed and heated in a microwave reactor at 100° C. for 15 min. The resultant brown oil was partitioned between dichloromethane and aqueous sodium bicarbonate solution. The organic layer was filtered through a hydrophobic frit and evaporated to give a brown oil (0.98 g). The oil was purified by silica gel chromatography using iso-hexanes/ethyl acetate 3:1 to yield the title compound (0.619 g, 74%) as a colorless oil. 1H NMR (300 MHz, CDCl3): δ 1.31 (t, J=7.1 Hz, 3H), 3.96 (d, J=12.0 Hz, 2H), 4.27 (q, J=7.1 Hz, 2H), 4.34-4.69 (m, 6H), 5.22-5.35 (m, 2H), 5.67-5.79 (m, 1H).