ethyl (2Z)-3-(pyridin-4-yl)but-2-enoate → Ethyl 3-(pyridin-4-yl)butanoate

HRID 2176891노트

반응식

HRID 2176891 반응식
[N:1]1[CH:6]=[CH:5][C:4](/[C:7](/[CH3:14])=[CH:8]\[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1>[Pd].CCO>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:14])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1

참가 물질

4

반응물 1

HCID 69315754ethyl (2Z)-3-(pyridin-4-yl)but-2-enoate

생성물 1

HCID 22277801Ethyl 3-(pyridin-4-yl)butanoate수율 71.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

Palladium on carbon (70 mg, 10 wt. %) was added to a solution of (Z)-ethyl 3-(pyridin-4-yl)but-2-enoate (0.70 g, 3.66 mmol) in EtOH (10 ml) and hydrogenated under balloon pressure for 18 h. The reaction mixture was filtered through a pad of celite and washed with EtOH. The filtrate was concentrated under reduced pressure to afford 0.50 g (71.4%) of ethyl 3-(pyridin-4-yl)butanoate as light brown color liquid.

후처리

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. washwashed with EtOH
  3. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e3eea5b8af234a3ab04fcbb65a93dd10
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067888B2

반응 노트

불러오는 중…