Ammonia → HCID 21973937, 화합물

반응식

[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:14])[CH2:8][C:9](OCC)=[O:10])=[CH:3][CH:2]=1.[NH3:15]>>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([CH3:14])[CH2:8][C:9]([NH2:15])=[O:10])=[CH:3][CH:2]=1

참가 물질

반응물 2

HCID 222Ammonia

HCID 22277801Ethyl 3-(pyridin-4-yl)butanoate

생성물 1

HCID 21973937HCID 21973937, 화합물수율 47%

실험 절차

A solution of ethyl 3-(pyridin-4-yl)butanoate (0.50 g, 2.59 mmol) in methanolic ammonia (10 ml) was heated to 100° C. in a pressure bomb for 48 h. The solvent was evaporated under reduced pressure to afford the crude compound, which was washed with n-pentane and dried under reduced pressure to afford 0.2 g (47%) of 3-(pyridin-4-yl)butanamide as an off-white solid.

후처리

customThe solvent was evaporated under reduced pressure
customto afford the crude compound, which
washwas washed with n-pentane
customdried under reduced pressure

출처 및 근거

ORD 기록: ord-bae163c026e14c37a50e9d65809f4649
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09067888B2

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