Potassium Carbonate → 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine

HRID 217691노트

반응식

HRID 217691 반응식
Br.[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1.C(=O)([O-])[O-].[K+].[K+]>O>[Cl:2][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([C:9]([NH2:12])=[N:10][N:11]=2)[N:8]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 866507946-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide

생성물 1

HCID 151078816-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-amine수율 30.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.001; 1.1 g) was taken up with a large amount of water and alkalized with saturated potassium carbonate solution. The solid which precipitated out was filtered off with suction and dried (388 mg). Repeated extraction of the mother liquor with dichloromethane, drying of the combined organic phases over sodium sulfate, filtration and concentration afforded a further 228 mg of product in total.

후처리

  1. customThe solid which precipitated out
  2. filtrationwas filtered off with suction
  3. customdried (388 mg)
  4. extractionextraction of the mother liquor with dichloromethane
  5. dry with materialdrying of the combined organic phases over sodium sulfate, filtration and concentration

출처 및 근거

ORD 기록
ord-3f4d53f273924bc791e4569682cc93f6
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198272B2

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