Ammonia → HCID 66869527, 화합물

반응식

[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[C:12]([CH2:14][C:15]([O:17]C)=O)[CH:11]=[CH:10][N:9]=2)[CH2:4][CH2:3]1.[NH3:19]>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[C:12]([CH2:14][C:15]([NH2:19])=[O:17])[CH:11]=[CH:10][N:9]=2)[CH2:4][CH2:3]1

참가 물질

반응물 2

HCID 222Ammonia

HCID 67382772HCID 67382772, 화합물

생성물 1

HCID 66869527HCID 66869527, 화합물수율 31%

실험 절차

A solution of methyl 2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetate (750 mg, 2.81 mmol) in methanolic ammonia (10 ml) was heated in a steel bomb at 90° C. for 72 h. The reaction mixture was cooled to room temperature, concentrated and dried in vacuum to afford the crude product. Purification by triturating with diethyl ether afforded 370 mg (31%) of 2-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)acetamide as a light brown color solid.

후처리

concentrationconcentrated
customdried in vacuum
customto afford the crude product
customPurification
customby triturating with diethyl ether

출처 및 근거

ORD 기록: ord-2ac5e599c5ff4ea392a173141b015e22
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09067888B2

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