Ammonia → (1R,3S)-3-(benzylamino)cyclopentanecarboxamide
반응식
[NH3:1].[CH2:2]([NH:9][C@H:10]1[CH2:14][CH2:13][C@@H:12]([C:15]([O:17]C)=O)[CH2:11]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO>[CH2:2]([NH:9][C@H:10]1[CH2:14][CH2:13][C@@H:12]([C:15]([NH2:1])=[O:17])[CH2:11]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1참가 물질
4
실험 절차
Ammonia gas was passed into a solution of (1R,3S)-methyl 3-(benzylamino)cyclopentanecarboxylate (250 mg, 1.14 mmol) in MeOH (5 ml) at −78° C. in a steel bomb. The reaction mixture was slowly warmed to room temperature, heated further to 100° C. and stirred for 24 h. The reaction mixture was concentrated and dried under vacuum to afford 250 mg of (1R,3S)-3-(benzylamino)cyclopentanecarboxamide with 50% purity as brown liquid which was proceeded as crude compound for the next step.
후처리
- temperatureheated further to 100° C.
- concentrationThe reaction mixture was concentrated
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-df395b029d1141e1ba16638f6e31a74e
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09067888B2
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