Acetic Acid → 2-(4-Chlorophenyl)-2-oxoethyl acetate

HRID 2177057

반응식

HRID 2177057 반응식
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:5]=1Br)=[O:3].[C:12]([OH:15])(=[O:14])[CH3:13].C(N(CC)CC)C>C(#N)C>[Cl:10][C:7]1[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH2:1][O:15][C:12](=[O:14])[CH3:13])=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 8471TriethylamineHCID 47126441-(2-Bromo-4-chlorophenyl)ethanone

생성물 1

HCID 5872542-(4-Chlorophenyl)-2-oxoethyl acetate수율 90.1%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
4 °C

실험 절차

To a cooled (4° C.) and stirred solution of 2-bromo-4-chloroacetophenone (5.0 g, 21.41 mmol) and glacial acetic acid (2.8 mL, 49.25 mmol) in acetonitrile was added triethylamine (6.1 mL, 44.97 mmol). The reaction mixture was warmed to room temperature, than refluxed for 3 hours. The reaction mixture was extracted with ether, acetate, washed with 1N hydrochloric acid, brine, dried, and concentrated to yield 4.1 g of acetic acid 2-(4-chlorophenyl)-2-oxo-ethyl ester.

후처리

  1. temperatureThe reaction mixture was warmed to room temperature
  2. temperaturethan refluxed for 3 hours
  3. extractionThe reaction mixture was extracted with ether, acetate
  4. washwashed with 1N hydrochloric acid, brine
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-254c1c65fedf4bc7b980642b38967d0e
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067897B2

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