Trifluoroacetic acid → N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-3-fluoropropane-1-sulfonamide trifluoroacetate

HRID 2177076노트

반응식

HRID 2177076 반응식
C(OC(=O)[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH2:18][NH:19][S:20]([CH2:23][CH2:24][CH2:25][F:26])(=[O:22])=[O:21])=[CH:13][CH:14]=2)[CH:9]1[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>ClCCl>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[NH2:7][CH:8]1[CH:9]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:10]2[CH:11]=[C:12]([CH2:18][NH:19][S:20]([CH2:23][CH2:24][CH2:25][F:26])(=[O:22])=[O:21])[CH:13]=[CH:14][C:15]=2[CH2:16][CH2:17]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 59547781HCID 59547781, 화합물

생성물 1

HCID 68507572N-{[7-Amino-8-benzyl-5,6,7,8-tetrahydronaphthalen-2-yl]methyl}-3-fluoropropane-1-sulfonamide trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Tert-butyl[1-benzyl-7-({[(3-fluoropropyl)sulfonyl]amino}methyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (9.3 mg, 0.019 mmol) was dissolved in dichloromethane (10 mL) and trifluoroacetic acid (excess) was added. The reaction mixture was stirred at room temperature for 4 h. The solvent was evaporated in vacuo and the crude product was purified by flash chromatography (silica gel, dichloromethane, methanol).

후처리

  1. customThe solvent was evaporated in vacuo
  2. customthe crude product was purified by flash chromatography (silica gel, dichloromethane, methanol)

출처 및 근거

ORD 기록
ord-1d820a63c5014f2eb2671ae21ed457f9
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067871B2

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