Potassium Hydroxide → Propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide

HRID 2177121노트

반응식

HRID 2177121 반응식
[CH:1]1([N:4]([S:11]([CH2:14][CH2:15][CH3:16])(=[O:13])=[O:12])[CH2:5][CH2:6][O:7]C(=O)C)[CH2:3][CH2:2]1.[OH-].[K+]>CO>[CH:1]1([N:4]([CH2:5][CH2:6][OH:7])[S:11]([CH2:14][CH2:15][CH3:16])(=[O:13])=[O:12])[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 59547802Acetic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester

생성물 1

HCID 43577530Propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide수율 32.6%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of acetic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester (1.7 g, 6.8 mmol) and KOH (0.57 g, 10.2 mmol) in 30 ml Methanol was stirred over night at room temperature. The solvent was evaporated the residue dissolved in ethyl acetate and subsequently extracted with water and 1 M KOH, dried over Na2SO4 and the solvent evaporated to obtain 0.46 g of product which was used purified by chromatography (253.5 mg of colorless oil)

후처리

  1. customThe solvent was evaporated the residue
  2. dissolutiondissolved in ethyl acetate
  3. extractionsubsequently extracted with water and 1 M KOH
  4. dry with materialdried over Na2SO4
  5. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-098e48aa23274b0582d1dabe0ca01b5c
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067871B2

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