2-Bromo-5-fluoropyridine → 1-(Pyrimidin-2-yl)-1H-imidazo[4,5-c]pyridine

반응식

F[C:2]1[CH:3]=C[C:5]([N:8]2[C:16]3[CH:15]=[CH:14][N:13]=[CH:12][C:11]=3[N:10]=[CH:9]2)=[N:6][CH:7]=1.BrC1C=CC(F)=C[N:19]=1>>[N:6]1[CH:7]=[CH:2][CH:3]=[N:19][C:5]=1[N:8]1[C:16]2[CH:15]=[CH:14][N:13]=[CH:12][C:11]=2[N:10]=[CH:9]1

참가 물질

반응물 2

HCID 27831712-Bromo-5-fluoropyridine

HCID 904095831-(5-Fluoropyridin-2-yl)-1H-imidazo[4,5-c]pyridine

생성물 1

HCID 904088391-(Pyrimidin-2-yl)-1H-imidazo[4,5-c]pyridine

실험 절차

Intermediate 5 was prepared in a manner analogous to Intermediate 1, substituting 2-bromopyrimidine for 2-bromo-5-fluoropyridine. MS (ESI): mass calculated for C10H7N5, 198.07. m/z found 199.1 [M+H]+.

출처 및 근거

ORD 기록: ord-4b171d88d45446f4b008ecc21e678c0c
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09066946B2

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