HCID 86271308, 화합물 → HCID 90409409, 화합물

HRID 2177591노트

반응식

HRID 2177591 반응식
[Cl:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([N:14]1[CH:19]=[CH:18][C:17]2[N:20]([C:23]3[CH:28]=[N:27][CH:26]=[CH:25][N:24]=3)[N:21]=[N:22][C:16]=2[CH:15]1[CH3:29])=[O:13]>CO.C1COCC1.[Pd]>[Cl:1][C:2]1[C:7]([C:8]([F:9])([F:11])[F:10])=[CH:6][CH:5]=[CH:4][C:3]=1[C:12]([N:14]1[CH2:19][CH2:18][C:17]2[N:20]([C:23]3[CH:28]=[N:27][CH:26]=[CH:25][N:24]=3)[N:21]=[N:22][C:16]=2[CH:15]1[CH3:29])=[O:13]

참가 물질

5

반응물 1

HCID 86271308HCID 86271308, 화합물

생성물 1

HCID 90409409HCID 90409409, 화합물

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A suspension of the 5-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-4-methyl-1-pyrazin-2-yl-4,5-dihydro-1H-[1,2,3]triazolo[4,5-c]pyridine (150 mg, 0.36 mmol) in MeOH (3.0 mL) and THF (1.0 mL) was treated with 10% Pd/C (30 mg), put under an atmosphere of H2 and stirred overnight. The reaction was filtered through Celite© and purified on 12 g SiO2 with 0-70% EA/DCM. MS (ESI): mass calcd. for C18H14ClF3N6O, 422.1. m/z found, 423.1 [M+H]+.

후처리

  1. filtrationThe reaction was filtered through Celite©
  2. custompurified on 12 g SiO2 with 0-70% EA/DCM

출처 및 근거

ORD 기록
ord-0ffed3ab3fb949d4b23f37b9e178e84c
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09066946B2

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