Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propionic Acid → 2-ethyl-1-phenyl-1H-imidazo[4,5-c]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propionic Acid | HCID 1032 | — |
| 반응물 | 4-N-phenylpyridine-3,4-diamine | HCID 10583675 | — |
| 용매 | Phosphorus oxychloride | HCID 24813 | — |
| 생성물 | 2-ethyl-1-phenyl-1H-imidazo[4,5-c]pyridine | HCID 90409595 | 19.3% |
반응 단계
A mixture of N4-phenylpyridine-3,4-diamine (8.0 g, 37.2 mmol), propionic acid (2.7 g, 37.2 mmol) and phosphorous oxychloride (50 mL) was stirred at reflux for 10 h. The reaction was purified by silica gel chromatography using ethyl acetate to afford the product as a solid (1.6 g, 19%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09066946B2 |
| 출처 데이터셋 | uspto-grants-2015_06 |
| ORD ID | ord-7cd3cb1fb65b4173a4000af600bf5e42 |
| 출처 메모 | uspto-grants-2015_06 |