Acetyl chloride → HCID 178469414, 화합물

HRID 2177722노트

반응식

HRID 2177722 반응식
C(Cl)(=O)C.[C:5]1([S:11]([CH2:14][C:15]2[C:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:19]([O:26][CH3:27])[C:18]([C:28]3[N:32](C4CCCCO4)[N:31]=[CH:30][CH:29]=3)=[CH:17][CH:16]=2)(=[O:13])=[O:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CO>[C:5]1([S:11]([CH2:14][C:15]2[C:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:19]([O:26][CH3:27])[C:18]([C:28]3[CH:29]=[CH:30][NH:31][N:32]=3)=[CH:17][CH:16]=2)(=[O:13])=[O:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 71268997Ethyl 6-(benzenesulphonylmethyl)-2-methoxy-3-[1-(tetrahydropyran-2-yl)pyrazol-5-yl]benzoate2회

생성물 1

HCID 178469414HCID 178469414, 화합물수율 99.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Acetyl chloride (0.1 ml) was added to methanol (10 ml) cooled in ice and the resultant solution was added to ethyl 6-(benzenesulphonylmethyl)-2-methoxy-3-[1-(tetrahydropyran-2-yl)pyrazol-5-yl]benzoate (Intermediate 47, 0.05 g). The resultant mixture was stirred at room temperature for 1 hour then evaporated to dryness. The residue was treated with sodium bicarbonate (saturated aqueous solution) and extracted with DCM, dried (MgSO4) and filtered. The filtrate was evaporated to dryness to give ethyl 6-(benzenesulphonylmethyl)-2-methoxy-3-(3-pyrazolyl)benzoate (0.041 g) as a gum.

후처리

  1. temperaturecooled in ice
  2. customthen evaporated to dryness
  3. additionThe residue was treated with sodium bicarbonate (saturated aqueous solution)
  4. extractionextracted with DCM
  5. dry with materialdried (MgSO4)
  6. filtrationfiltered
  7. customThe filtrate was evaporated to dryness

출처 및 근거

ORD 기록
ord-9fc4b3acbf2c4ef9b612f2b423b6ba4f
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067905B2

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