Dichloromethane → 3-(4-Bromophenyl)propyl methanesulphonate

HRID 217784

반응식

HRID 217784 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][OH:11])=[CH:4][CH:3]=1.ClCCl.[CH3:15][S:16](Cl)(=[O:18])=[O:17]>C(N(CC)CC)C>[CH3:15][S:16]([O:11][CH2:10][CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)(=[O:18])=[O:17]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 105606143-(4-Bromophenyl)propan-1-ol

생성물 1

HCID 196884663-(4-Bromophenyl)propyl methanesulphonate수율 91.5%

시약·촉매·용매 1

HCID 8471Triethylamine용매

반응 조건

온도
0 °C

실험 절차

3-(4-Bromophenyl)propan-1-ol (335 g) and dichloromethane (2.5 L) was charged into Reactor 1. Reactor 1 was adjusted to −10 to 0° C. Triethylamine (205 g) was charged into Reactor 1. Methanesulphonyl chloride (272.7 g) was added dropwise into Reactor 1 maintaining contents at <0° C. Reactor 1 was stirred at −5 to 5° C. for 1 h then analysed for reaction completion. The organic layer was washed with water (1 L) and saturated NaCl solution (1 L). The organic layer was evaporated down to dryness to give 3-(4-bromophenyl)propyl methanesulfonate (418 g).

후처리

  1. customReactor 1 was adjusted to −10 to 0° C
  2. customthen analysed for reaction completion
  3. washThe organic layer was washed with water (1 L) and saturated NaCl solution (1 L)
  4. customThe organic layer was evaporated down to dryness

출처 및 근거

ORD 기록
ord-7e3f71f2fd514fcd9d7d6fb40e69d52f
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08198285B2

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