Furan-3-boronic acid → (Z)-methyl 6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-3-(furan-3-yl)-2-hydroxybenzoate

HRID 2177841노트

반응식

HRID 2177841 반응식
[CH2:1]([N:3]([CH2:35][CH3:36])[CH2:4]/[CH:5]=[CH:6]\[C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[S:14]([CH2:17][C:18]1[C:23]([C:24]([O:26][CH3:27])=[O:25])=[C:22]([O:28]C)[C:21]([C:30]2[CH:34]=[CH:33][O:32][CH:31]=2)=[CH:20][CH:19]=1)(=[O:16])=[O:15])[CH3:2].BrC1C(O)=C(C(CS(C2C=CC(F)=CC=2/C=C\CN(CC)CC)(=O)=O)=CC=1)C(OC)=O.O1C=CC(B(O)O)=C1>>[CH2:35]([N:3]([CH2:1][CH3:2])[CH2:4]/[CH:5]=[CH:6]\[C:7]1[CH:12]=[C:11]([F:13])[CH:10]=[CH:9][C:8]=1[S:14]([CH2:17][C:18]1[C:23]([C:24]([O:26][CH3:27])=[O:25])=[C:22]([OH:28])[C:21]([C:30]2[CH:34]=[CH:33][O:32][CH:31]=2)=[CH:20][CH:19]=1)(=[O:15])=[O:16])[CH3:36]

참가 물질

4

반응물 3

HCID 2734358Furan-3-boronic acidHCID 66693503(Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-hydroxybenzoate2회HCID 69915014(Z)-methyl 6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-3-(furan-3-yl)-2-methoxybenzoate

생성물 1

HCID 86677120(Z)-methyl 6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-3-(furan-3-yl)-2-hydroxybenzoate

실험 절차

Prepared by proceeding in a similar manner to Intermediate 160, starting from (Z)-methyl 3-bromo-6-((2-(3-(diethylamino)prop-1-enyl)-4-fluorobenzenesulfonyl)methyl)-2-hydroxybenzoate (Intermediate 197) and furan-3-boronic acid.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-dc9cbbdf33274665a329441a29bb17b4
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067905B2

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