Ethyl Acetate → 4-Formyl-2-nitrobenzoic acid
반응식
[CH:1]([C:3]1[CH:10]=[CH:9]C(C#N)=[C:5]([N+:11]([O-:13])=[O:12])[CH:4]=1)=[O:2].CC[O:16][C:17]([CH3:19])=[O:18]>S(=O)(=O)(O)O.O>[CH:1]([C:3]1[CH:10]=[CH:9][C:19]([C:17]([OH:16])=[O:18])=[C:5]([N+:11]([O-:13])=[O:12])[CH:4]=1)=[O:2]참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 4-formyl-2-nitrobenzonitrile (150 mg, 0.85 mmol) in conc. sulfuric acid (2 mL) and water (4 mL) was heated at 100° C. for 13 hours. Followed standard aqueous/EtOAc workup to give Intermediate 73.
출처 및 근거
- ORD 기록
- ord-e9f4d6dda7ca41f1b0dc25b75ba36fbc
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09067893B2
반응 노트
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