Trifluoromethanesulfonic anhydride → HCID 88853052, 화합물

HRID 2178099노트

반응식

HRID 2178099 반응식
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[O:14](S(C(F)(F)F)(=O)=O)[S:15]([C:18]([F:21])([F:20])[F:19])(=O)=[O:16]>C(Cl)Cl>[F:19][C:18]([F:21])([F:20])[S:15]([O:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[C:10]([F:11])([F:12])[F:13])(=[O:16])=[O:14]

참가 물질

4

반응물 2

HCID 67749Trifluoromethanesulfonic anhydrideHCID 70215934-Hydroxy-3-(trifluoromethyl)benzaldehyde

생성물 1

HCID 88853052HCID 88853052, 화합물수율 66%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of 4-hydroxy-3-(trifluoromethyl)benzaldehyde (500 mg, 2.7 mmol), TEA (805 mg, 8.0 mmol) in anhydrous DCM (10 mL) was added Tf2O (820 mg, 2.9 mmol) drop wise at 0° C., and stirred at the same temperature for 30 mins. Followed a standard aqueous/EtOAc workup and purified by column chromatography (PE:EtOAc=10:1) to give product (560 mg, 66% yield).

후처리

  1. customFollowed a standard aqueous/EtOAc workup and purified by column chromatography (PE:EtOAc=10:1)

출처 및 근거

ORD 기록
ord-4e41a3fb0f844b3c9596ae8a6271c0f5
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067893B2

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