4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole → 4-(8-methoxy-1-((S)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole

HRID 2178586노트

반응식

HRID 2178586 반응식
[CH3:1][O:2][C:3]1[C:12]([C:13]2[C:14]([CH3:19])=[N:15][O:16][C:17]=2[CH3:18])=[CH:11][C:10]2[N:9]=[CH:8][C:7]3[N:20]=[C:21]([CH:28]4[CH2:33][CH2:32][O:31][CH2:30][CH2:29]4)[N:22]([CH:23]([CH3:27])[CH2:24][O:25][CH3:26])[C:6]=3[C:5]=2[CH:4]=1>C(O)C>[CH3:1][O:2][C:3]1[C:12]([C:13]2[C:14]([CH3:19])=[N:15][O:16][C:17]=2[CH3:18])=[CH:11][C:10]2[N:9]=[CH:8][C:7]3[N:20]=[C:21]([CH:28]4[CH2:29][CH2:30][O:31][CH2:32][CH2:33]4)[N:22]([C@@H:23]([CH3:27])[CH2:24][O:25][CH3:26])[C:6]=3[C:5]=2[CH:4]=1

참가 물질

3

반응물 1

HCID 712589164-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole

생성물 1

HCID 712590474-(8-methoxy-1-((S)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole수율 44.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole (85 mg) was dissolved in ethanol (ca. 4 ml) with heating and sonication. Injections (400 μl) were then made via plastic syringe. The fractions between 24 min and 26.5 min were collected and the combined fraction solutions were evaporated to dryness using a rotary evaporator (30° C. bath temp). The residue was transferred to a tared glass vial using ethanol (ca 12 ml). The solvent was then removed by evaporation under a stream of nitrogen gas (room temp) to give 4-(8-methoxy-1-((S)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole (38 mg).

후처리

  1. temperaturewith heating
  2. customsonication
  3. customInjections (400 μl) were then made via plastic syringe
  4. customThe fractions between 24 min and 26.5 min were collected
  5. customthe combined fraction solutions were evaporated to dryness
  6. customa rotary evaporator (30° C. bath temp)
  7. customThe solvent was then removed by evaporation under a stream of nitrogen gas (room temp)

출처 및 근거

ORD 기록
ord-d0485999d0c94aa7a9fa1dec8f425f22
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067936B2

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