3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole → 4-(benzyloxy)-1-methyl-2-(trifluoromethyl)-1H-indole

HRID 2178723노트

반응식

HRID 2178723 반응식
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[CH:12][N:13]2[CH3:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC1(C)C2C=CC=CC=2I([C:29]([F:32])([F:31])[F:30])O1>C([O-])(=O)C.[Cu+]>[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[C:12]([C:29]([F:32])([F:31])[F:30])[N:13]2[CH3:18])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 160435723,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxoleHCID 247769014-(Benzyloxy)-1-methyl-1H-indole

생성물 1

HCID 683797834-(benzyloxy)-1-methyl-2-(trifluoromethyl)-1H-indole

시약·촉매·용매 1

HCID 69023Cuprous acetate촉매

실험 절차

4-(Benzyloxy)-1-methyl-1H-indole and 3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole were treated with copper(I) acetate to give 4-(benzyloxy)-1-methyl-2-(trifluoromethyl)-1H-indole. Debenzylation via transfer hydrogenation with ammonium formate afforded 1-methyl-2-(trifluoromethyl)-1H-indol-4-ol.

출처 및 근거

ORD 기록
ord-380d383cf6374bb3a8148a67c39f651b
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067934B2

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