HCID 86643578, 화합물 → 1-Chloro[1]benzothieno[2,3-c]pyridine

HRID 2178740노트

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HRID 2178740 반응식
[Cl:1][C:2]1[C:7]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:6](N)[CH:5]=[CH:4][N:3]=1>CC(O)=O>[Cl:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 1

HCID 86643578HCID 86643578, 화합물

생성물 1

HCID 8198151-Chloro[1]benzothieno[2,3-c]pyridine수율 88%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a 250 mL round flask was added 2-chloro-3-phenylthio-4-aminopyridine (2.7 g, 11.4 mmol), and 60 mL of glacial AcOH. To this clear solution, ButONO (1.36 g, 11.45 mmol) was added drop by drop. After stirring at room temperature for 1 h, another (1.36 g 11.45) mmol of ButONO was added. The mixture was continued to stir at room temperature for 18 h. The reaction was quenched by water, and the product was purified by a silica gel column. Yield (88%) of 1-chloro-benzothieno[2,3-c]pyridine was 2.2 g.

후처리

  1. additionTo this clear solution, ButONO (1.36 g, 11.45 mmol) was added drop by drop
  2. stirringto stir at room temperature for 18 h
  3. customThe reaction was quenched by water
  4. customthe product was purified by a silica gel column

출처 및 근거

ORD 기록
ord-0abf20417624463aaf815d0834d3bbe8
출처 데이터셋
uspto-grants-2015_06
특허 번호
US09067947B2

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