Diethyl Ether → HCID 59212660, 화합물
반응식
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[F:12][C:13]([F:25])([F:24])[C:14]1[CH:22]=[C:21]2[C:17]([CH:18]=[CH:19][CH:20]2[OH:23])=[CH:16][CH:15]=1.CCOCC>C(Cl)Cl>[F:12][C:13]([F:24])([F:25])[C:14]1[CH:22]=[C:21]2[C:17]([CH:18]=[CH:19][C:20]2=[O:23])=[CH:16][CH:15]=1참가 물질
5
실험 절차
To a solution of pyridinium chlorochromate (1.08 g, 5.0 mmol) in methylene chloride (15 mL) was added dropwise a solution of 6-(trifluoromethyl)-1H-inden-1-ol (500 mg, 2.498 mmol) in methylene chloride (10 mL). After being stirred for 14 h, ether (30 mL) was added, and the reaction mixture was filtered through silica gel. The filtrate was concentrated in vacuo. The crude material was chromatographed (10:1 hexane/EtOAc) to afford 200 mg (40%) of the product. LC-MS [M+1]=199.2.
후처리
- filtrationthe reaction mixture was filtered through silica gel
- concentrationThe filtrate was concentrated in vacuo
- customThe crude material was chromatographed (10:1 hexane/EtOAc)
출처 및 근거
- ORD 기록
- ord-67288fb05b7b447cb094e9b7594a1b3a
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09067921B2
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