4-(2-Bromoethyl)pyridine hydrobromide → 5-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-(2-pyridin-4-yl-ethyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine

반응식

[C:1]([C:5]1[N:6]=[C:7]([N:16]2[CH2:20][CH2:19][C:18]([F:22])([F:21])[CH2:17]2)[C:8]2[C:9](=[N:11][N:12]([CH2:14][CH3:15])[N:13]=2)[N:10]=1)([CH3:4])([CH3:3])[CH3:2].C(C1N=[C:29]([N:36]2[CH2:40][CH2:39][C:38](F)(F)[CH2:37]2)C2N=NNC=2N=1)(C)(C)C.Br.BrCCC1C=CN=CC=1>>[C:1]([C:5]1[N:6]=[C:7]([N:16]2[CH2:20][CH2:19][C:18]([F:21])([F:22])[CH2:17]2)[C:8]2[C:9](=[N:11][N:12]([CH2:14][CH2:15][C:38]3[CH:37]=[CH:29][N:36]=[CH:40][CH:39]=3)[N:13]=2)[N:10]=1)([CH3:2])([CH3:3])[CH3:4]

참가 물질

반응물 3

HCID 219962524-(2-Bromoethyl)pyridine hydrobromide

HCID 715763075-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine

HCID 178441789HCID 178441789, 화합물

생성물 1

HCID 715758525-tert-Butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-(2-pyridin-4-yl-ethyl)-2H-[1,2,3]triazolo[4,5-d]pyrimidine

실험 절차

In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine (example 3, step b), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 4-(2-bromoethyl)pyridine hydrobromide and isolated as white solid. MS (m/e): 388.3 (MH+).