3-(chloromethyl)-4,5-dimethyl-4H-1,2,4-triazole → HCID 71576038, 화합물
반응식
[C:1]([C:5]1[N:6]=[C:7]([N:16]2[CH2:20][CH2:19][C:18]([F:22])([F:21])[CH2:17]2)[C:8]2[C:9](=[N:11][N:12]([CH2:14][CH3:15])[N:13]=2)[N:10]=1)([CH3:4])([CH3:3])[CH3:2].C([C:27]1N=C(N2CCC(F)(F)C2)[C:30]2N=[N:34][NH:33][C:31]=2[N:32]=1)(C)(C)C.ClCC1N(C)C(C)=NN=1>>[C:1]([C:5]1[N:6]=[C:7]([N:16]2[CH2:20][CH2:19][C:18]([F:21])([F:22])[CH2:17]2)[C:8]2[C:9](=[N:11][N:12]([CH2:14][C:15]3[N:32]([CH3:27])[C:31]([CH3:30])=[N:33][N:34]=3)[N:13]=2)[N:10]=1)([CH3:2])([CH3:3])[CH3:4]참가 물질
4
실험 절차
In analogy to the procedure described for the synthesis of 5-tert-butyl-7-(3,3-difluoro-pyrrolidin-1-yl)-2-ethyl-2H-[1,2,3]triazolo[4,5-d]pyrimidine (example 3, step b), the title compound was prepared from 5-tert-butyl-7-(3,3-difluoropyrrolidin-1-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine and 3-(chloromethyl)-4,5-dimethyl-4H-1,2,4-triazole and isolated as light yellow solid. MS (m/e): 392.3 (MH+).