3-Pyrroline → HCID 67314806, 화합물

반응식

[ClH:1].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[C@@H:4]([NH:10][C:11]([C:13]1[S:14][C:15]3[C:21]([C:22]4[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=4)[C:25]([OH:27])=O)=[CH:20][CH:19]=[CH:18][C:16]=3[CH:17]=1)=[O:12])[CH2:3]2.[NH:31]1[CH2:35][CH:34]=[CH:33][CH2:32]1>>[ClH:1].[N:2]12[CH2:7][CH2:6][CH:5]([CH2:8][CH2:9]1)[C@@H:4]([NH:10][C:11]([C:13]1[S:14][C:15]3[C:21]([C:22]4[CH:30]=[CH:29][CH:28]=[C:24]([C:25]([N:31]5[CH2:35][CH:34]=[CH:33][CH2:32]5)=[O:27])[CH:23]=4)=[CH:20][CH:19]=[CH:18][C:16]=3[CH:17]=1)=[O:12])[CH2:3]2

참가 물질

반응물 2

HCID 660593-Pyrroline

HCID 67314106HCID 67314106, 화합물

생성물 1

HCID 67314806HCID 67314806, 화합물

실험 절차

50 mg (0.11 mmol) of 3-(2-{[(3R)-1-azabicyclo[2.2.2]oct-3-ylamino]carbonyl}-1-benzothien-7-yl)benzoic acid hydrochloride (Example 75) and 15.6 mg (0.23 mmol) of 3-pyrroline are reacted together by general method E. 20 mg (35.9% of theory) of the title compound are obtained.

출처 및 근거

ORD 기록: ord-35a0f294b0884caa8b9600be1c24f5fb
출처 데이터셋: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09067931B2

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