Triethylamine → HCID 58111022, 화합물
반응식
[CH3:1][C:2]1([CH3:22])[C@@H:5]([C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[O:7])[CH2:4][C@H:3]1[NH:14]C(=O)OC(C)(C)C.CCN(CC)CC>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:14][C@@H:3]1[CH2:4][C@H:5]([C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[O:7])[C:2]1([CH3:22])[CH3:1]참가 물질
4
실험 절차
Tert-butyl (1R,3S)-2,2-dimethyl-3-(morpholine-4-carbonyl)cyclobutylcarbamate (Step 1, 0.260 g, 0.833 mmol) was taken in TFA:DCM (1:4) (3 ml) at 0° C.-room temperature and stirred for 1 hour. After completion of the reaction the solvent was evaporated and the crude dissolved in DCM and basified with Et3N (0.7 ml, 5.0 mmol). The resulting solution as such used for next reaction immediately. Wt: 0.176 g.
후처리
- customAfter completion of the reaction the solvent
- customwas evaporated
- dissolutionthe crude dissolved in DCM
- customThe resulting solution as such used for next reaction immediately
출처 및 근거
- ORD 기록
- ord-5a5876f6a588474c8f65e636832d1790
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09067966B2
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