Triethylamine → HCID 58111068, 화합물
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[CH3:1][C:2]1([CH3:21])[C@@H:5]([C:6]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)=[O:7])[CH2:4][C@H:3]1[NH:13]C(=O)OC(C)(C)C.CCN(CC)CC>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:13][C@@H:3]1[CH2:4][C@H:5]([C:6]([N:8]2[CH2:12][CH2:11][CH2:10][CH2:9]2)=[O:7])[C:2]1([CH3:21])[CH3:1]참가 물질
4
실험 절차
A solution of tert-butyl (1R,3S)-2,2-dimethyl-3-(pyrrolidine-1-carbonyl)cyclobutylcarbamate (step 1, 0.400 g, 1.351 mmol) in TFA:DCM (1:2) (3 ml) stirred at 0° C.-room temperature for about 1 hour. After completion of the reaction, the solvent was evaporated and the crude was dissolved in DCM and basified with Et3N (1.124 ml, 8.108 mmol) the resulting solution as such used for next reaction immediately. Wt: 0.264 g (Based on 100% yield calculated and proceeded for next reaction).
후처리
- customAfter completion of the reaction
- customthe solvent was evaporated
- dissolutionthe crude was dissolved in DCM
- customas such used for next reaction immediately
- customWt: 0.264 g (Based on 100% yield calculated and proceeded for next reaction)
출처 및 근거
- ORD 기록
- ord-25748ac1e5c447498c5ca6faf5f9ad0d
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09067966B2
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