Water → HCID 69799515, 화합물

HRID 2179982노트

반응식

HRID 2179982 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[O:9][C@@H:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:11][CH2:12]I.[NH2:20][CH2:21][CH2:22][CH2:23][OH:24].O>CN(C)C=O>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[O:9][C@@H:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:11][CH2:12][NH:20][CH2:21][CH2:22][CH2:23][OH:24]

참가 물질

5

반응물 3

HCID 962WaterHCID 90863-Amino-1-propanolHCID 69799252HCID 69799252, 화합물

생성물 1

HCID 69799515HCID 69799515, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The product of step (b) (0.2 g) and 3-amino-propanol (0.11 g) were dissolved in dimethylformamide (4 ml) and stirred for 24 h. The reaction was poured into water and extracted into ethyl acetate. The organic extract was washed with brine, dried over magnesium sulphate and evaporated to dryness and triturated with 1N HCl in ether to give the product as a white solid.

후처리

  1. extractionextracted into ethyl acetate
  2. extractionThe organic extract
  3. washwas washed with brine
  4. dry with materialdried over magnesium sulphate
  5. customevaporated to dryness
  6. customtriturated with 1N HCl in ether

출처 및 근거

ORD 기록
ord-99a4545c79eb4df79264a21932f1e55c
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06887871B2

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