tert-Butyl piperazine-1-carboxylate → HCID 69803723, 화합물

반응식

[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:10][C@@H:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:12][CH2:13]Cl)[CH:3]=1.[N:21]1([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH:3]=1)[O:10][C@@H:11]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[CH2:12][CH2:13][N:24]1[CH2:23][CH2:22][N:21]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:26][CH2:25]1

참가 물질

반응물 2

HCID 143452tert-Butyl piperazine-1-carboxylate

HCID 20779195HCID 20779195, 화합물

생성물 1

HCID 69803723HCID 69803723, 화합물수율 78.3%

실험 절차

4-Chloro-2-{[(1R)-3-chloro-1-phenylpropyl]oxy}benzonitrile (0.3 g) and 1,1-dimethylethyl piperazinecarboxylate (0.4 g) were subjected to the procedure described for Example 11 to give the product as a clear gum (0.35 g).

출처 및 근거

ORD 기록: ord-7c06e1c6040f4e24806692919c4a7b9c
출처 데이터셋: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06887871B2

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