[2-Methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-yl]-hydrazine → 3-(3,5-Diethyl-pyrazol-1-yl)-2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridine

HRID 2180002노트

반응식

HRID 2180002 반응식
[CH3:1][O:2][C:3]1[C:8]([NH:9][NH2:10])=[CH:7][C:6]([CH3:11])=[C:5]([C:12]2[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][C:13]=2[O:23][CH3:24])[N:4]=1>CCO>[CH2:7]([C:6]1[CH:5]=[C:12]([CH2:13][CH3:14])[N:9]([C:8]2[C:3]([O:2][CH3:1])=[N:4][C:5]([C:12]3[CH:17]=[CH:16][C:15]([O:18][C:19]([F:21])([F:22])[F:20])=[CH:14][C:13]=3[O:23][CH3:24])=[C:6]([CH3:11])[CH:7]=2)[N:10]=1)[CH3:8]

참가 물질

3

반응물 1

HCID 22490050[2-Methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-yl]-hydrazine

생성물 1

HCID 101814093-(3,5-Diethyl-pyrazol-1-yl)-2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Preparation of 3-(3,5-Diethyl-pyrazol-1-yl)-2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridine 3,5-heptane dione (0.32 ml, 2.33 mmol) is added to a solution of [2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-yl]-hydrazine (0.8 g, 2.33 mmol) in EtOH (15 ml) at room temperature. The mixture is refluxed for 15 hours. The solvent is removed under reduced pressure and the residue is purified by flash column chromatography to obtain 3-(3,5-Diethyl-pyrazol-1-yl)-2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridine (Compound 4). Rf(hexane/EtOAc=9:1)=0.18, MS m/z 436.4 (M+H).

후처리

  1. temperatureThe mixture is refluxed for 15 hours
  2. customThe solvent is removed under reduced pressure
  3. customthe residue is purified by flash column chromatography

출처 및 근거

ORD 기록
ord-d08e34b4cbcf45219756d57e2faba052
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06887875B2

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