반응식
[Cl-].[NH4+].[F:3][C:4]1([F:34])[O:8][C:7]2[CH:9]=[C:10]([N+:31]([O-])=O)[CH:11]=[C:12]([C@@:13]34[N:22]=[C:21]([NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])[S:20][CH2:19][C@@H:18]3[CH2:17][CH2:16][O:15][CH2:14]4)[C:6]=2[O:5]1>C(O)C.[Fe]>[NH2:31][C:10]1[CH:11]=[C:12]([C@@:13]23[N:22]=[C:21]([NH:23][C:24](=[O:30])[O:25][C:26]([CH3:28])([CH3:27])[CH3:29])[S:20][CH2:19][C@@H:18]2[CH2:17][CH2:16][O:15][CH2:14]3)[C:6]2[O:5][C:4]([F:3])([F:34])[O:8][C:7]=2[CH:9]=1참가 물질
5
반응물 2
생성물 1
시약·촉매·용매 2
실험 절차
Iron powder (7.09 mg) and a saturated ammonium chloride solution (1.0 ml) were added to a solution of tert-butyl (±)-[(4aR*,8aS*)-8a-(2,2-difluoro-6-nitrobenzo[1,3]dioxol-4-yl)-4,4a,5,6,8,8a-hexahydro-7-oxa-3-thia-1-azanaphthalen-2-yl]carbamate (60.0 mg) in ethanol (20 ml), and the mixture was heated under reflux for 30 minutes. The reaction solution was returned to room temperature and the insoluble matter was removed by filtration through celite. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography to obtain the title compound (50.0 mg).
후처리
- temperaturethe mixture was heated
- temperatureunder reflux for 30 minutes
- customwas returned to room temperature
- customthe insoluble matter was removed by filtration through celite
- customThe solvent was evaporated under reduced pressure
- customthe residue was purified by silica gel column chromatography
출처 및 근거
- ORD 기록
- ord-20c13fc941d848969a7f0d203b87fff9
- 출처 데이터셋
- uspto-grants-2012_06
- 특허 번호
- US08198269B2
연결된 노트
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