7-Benzyloxy-4-chloro-6-methoxycinnoline hydrochloride → 4-Chloro-7-hydroxy-6-methoxycinnoline

참여 물질

반응 단계

A solution of 7-benzyloxy-4-chloro-6-methoxycinnoline hydrochloride (3.06 g, 9 mmol), in TFA (30 ml) was heated at reflux for 5 hours. After evaporation of the solvent, the residue was suspended in water and adjusted to pH7 with saturated aqueous sodium hydrogen carbonate solution. The resulting solid was filtered off, washed with water and ether and dried under vacuum to give 4-chloro-7-hydroxy-6-methoxycinnoline as a yellow solid (1.78 g, 94%).

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