Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoate → HCID 86759717, 화합물

HRID 2180628노트

반응식

HRID 2180628 반응식
C(OP([CH2:9]/[C:10](/[CH3:17])=[CH:11]/[C:12]([O:14][CH2:15][CH3:16])=[O:13])(OCC)=O)C.[Br:18][C:19]1[C:28]2[C:27]([CH3:30])([CH3:29])[CH2:26][CH:25]=[C:24]([CH:31]([CH3:33])[CH3:32])[C:23]=2[CH:22]=[C:21](/[C:34](/[CH3:39])=[C:35](/[F:38])\[CH:36]=O)[C:20]=1[O:40][CH2:41][CH3:42]>>[Br:18][C:19]1[C:28]2[C:27]([CH3:30])([CH3:29])[CH2:26][CH:25]=[C:24]([CH:31]([CH3:33])[CH3:32])[C:23]=2[CH:22]=[C:21](/[C:34](/[CH3:39])=[C:35](/[F:38])\[CH:36]=[CH:9]\[C:10](\[CH3:17])=[CH:11]\[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:20]=1[O:40][CH2:41][CH3:42]

참가 물질

3

반응물 2

HCID 6000084Ethyl 4-(diethoxyphosphoryl)-3-methylbut-2-enoateHCID 22491001HCID 22491001, 화합물

생성물 1

HCID 86759717HCID 86759717, 화합물

실험 절차

Following General Procedure I-1, ethyl 4-(diethoxyphosphoryl)-3-methyl-but-2E-enoate (1.3 g, 4.95 nmol) and (2E)-3-(4-bromo-3-ethoxy-8-isopropyl-5,5-dimethyl-5,6-dihydro-naphthalen-2-yl)-2-fluoro-but-2-enal (Compound A-147, 675 mg, 1.65 mmol) were reacted to give the title compound as a colorless oil after purification by column chromatography (silica gel, 2% ethyl acetate in hexane).

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-61201d1b8cfe421691ae6ec140d3279c
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06887896B1

반응 노트

불러오는 중…