Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N4-Acetylsulfanilamide → 4-(4-Acetylamino-benzenesulfonylamino)-3-hydroxy-4-oxo-but-2-enoic acid (4-fluoro-benzyl)-methoxy-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N4-Acetylsulfanilamide | HCID 8482 | — |
| 반응물 | 2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide | HCID 73033233 | — |
| 생성물 | 4-(4-Acetylamino-benzenesulfonylamino)-3-hydroxy-4-oxo-but-2-enoic acid (4-fluoro-benzyl)-methoxy-amide | HCID 76169159 | — |
반응 단계
2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with N-(4-sulfamoyl-phenyl)-acetamide as described in the preparation of compound 1 to yield the title compound. 1H NMR (500 MHz, DMSO) δ: 2.07 (s, 3), 3.60 (s, 3), 4.71 (s, 2), 6.26 (s, 1), 6.94 (m, 2), 7.21 (m, 2), 7.72 (m, 2), 7.86 (m, 2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06890942B2 |
| 출처 데이터셋 | uspto-grants-2005_05 |
| ORD ID | ord-9d99fefc4ecb4149843473aee44ee085 |
| 출처 메모 | uspto-grants-2005_05 |