1-Benzylcyclopropane-1-sulfonamide → HCID 72613066, 화합물

HRID 2181110노트

반응식

HRID 2181110 반응식
CC1(C)[O:6][C:5](=[CH:7][C:8]([N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[O:11][CH3:12])=[O:9])[C:4](=[O:21])O1.[CH2:23]([C:30]1([S:33]([NH2:36])(=[O:35])=[O:34])[CH2:32][CH2:31]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[F:20][C:17]1[CH:16]=[CH:15][C:14]([CH2:13][N:10]([O:11][CH3:12])[C:8](=[O:9])[CH:7]=[C:5]([OH:6])[C:4]([NH:36][S:33]([C:30]2([CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:32][CH2:31]2)(=[O:34])=[O:35])=[O:21])=[CH:19][CH:18]=1

참가 물질

3

반응물 2

HCID 218897981-Benzylcyclopropane-1-sulfonamideHCID 730332332-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide

생성물 1

HCID 72613066HCID 72613066, 화합물

실험 절차

2-(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-ylidene)-N-(4-fluoro-benzyl)-N-methoxy-acetamide was treated with 1-benzyl-cyclopropanesulfonic acid amide as described in the preparation of compound 1 to yield the title compound. MS (M−H) calcd for C22H22FN2O6S: 461.1. Found: 461.2. HRMS (M+H) calcd for C22H24FN2O6S: 463.1339. Found: 463.1331. 1H NMR (500 MHz, CDCl3) 0.95 (m, 2), 1.26 (m, 2), 3.25 (s, 2), 3.85 (s, 3), 4.79 (s, 2), 6.43 (s, 1), 7.06-7.32 (overlapping m, 9). Anal calcd for C22H23FN2O6S: C, 57.13; H, 5.01; N, 6.05. Found: C, 56.06; H, 5.42; N, 6.25.

출처 및 근거

ORD 기록
ord-f09c173a1ee34bfc979885b828225d54
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06890942B2

반응 노트

불러오는 중…