1H-Indene, 2-(1-methylethyl)-4-phenyl- → Lithium 2-isopropyl-4-phenylindenide

HRID 2181374노트

반응식

HRID 2181374 반응식
[CH:1]([C:4]1[CH2:5][C:6]2[C:11]([CH:12]=1)=[C:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:9]=[CH:8][CH:7]=2)([CH3:3])[CH3:2].C([Li:23])CCC>C1(C)C=CC=CC=1>[CH:1]([C:4]1[CH-:5][C:6]2[C:11]([CH:12]=1)=[C:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:9]=[CH:8][CH:7]=2)([CH3:3])[CH3:2].[Li+:23]

참가 물질

4

반응물 2

HCID 180082381H-Indene, 2-(1-methylethyl)-4-phenyl-HCID 178418339Butyllithium

생성물 1

HCID 22023052Lithium 2-isopropyl-4-phenylindenide수율 93.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a toluene solution (25 ml) of 2-isopropyl-4-phenylindene (3.34 g, 14.25 mmol), in a glovebox filled with argon, was added n-butyl lithium (5.500 ml, 13.75 mmol). The mixture was stirred at room temperature overnight. The toluene was removed under reduced pressure. Hexane (20 ml) was added and removed under reduced pressure then added again (50 ml). The mixture was stirred for 1 h then filtered, washed with about 15 ml hexane and the filtrate dried under vacuum. The lithium indenide product (3.09 g) was obtained as an orange-brown powder. This material was stored in the glovebox until needed.

후처리

  1. customThe toluene was removed under reduced pressure
  2. additionHexane (20 ml) was added
  3. customremoved under reduced pressure
  4. additionthen added again (50 ml)
  5. stirringThe mixture was stirred for 1 h
  6. filtrationthen filtered
  7. washwashed with about 15 ml hexane
  8. customthe filtrate dried under vacuum

출처 및 근거

ORD 기록
ord-664f7e6dbc4045d5b985f6cdbd068f39
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06891005B2

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