참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tributylvinyltin | HCID 81998 | — |
| 반응물 | 5-Chloro-2-(4-fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)imidazo[4,5-b]pyridine | HCID 22486152 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 5Chloro-2-(4fluorophenyl)imidazo[4,5-b]pyridine | HCID 22486125 | 141.3% |
반응 단계
2-(4-Fluorophenyl)-1-(2-cyclopentylamino-4-pyrimidinyl)-5-chloroimidazo[4,5-b]pyridine (50 mg 0.12 mmol), vinyltributylstannane (4.3 ml 0.15 mmol) and PdCl2(PPh3)2 (8.6 mg 0.01 mmol) are dissolved in xylene (1 ml) and heated to 160° C. for 1 h under argon. The reaction mixture is purified over SiO2 (acetone/hexanes 15/85) to yield the title compound as colorless crystals (42 mg 86%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06891039B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_05 |
|---|
| ORD ID | ord-b18448ed9fd14013ad73d5b6df265a01 |
|---|
| 출처 메모 | uspto-grants-2005_05 |
|---|
