Formic Acid → 588702-95-8

HRID 2181656노트

반응식

HRID 2181656 반응식
C([O:3][CH:4](OCC)[C:5]1[O:6][C:7]2[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[CH:10][C:8]=2[CH:9]=1)C.C(O)=O>O>[CH:4]([C:5]1[O:6][C:7]2[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[CH:10][C:8]=2[CH:9]=1)=[O:3]

참가 물질

4

반응물 2

HCID 284Formic AcidHCID 22481729HCID 22481729, 화합물

생성물 1

HCID 22481722588702-95-8수율 94%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

Methyl 2-(diethoxymethyl)-1-benzofuran-6-carboxylate (2.71 g, 9.7 mmol) is treated drop-wise with formic acid (20 ml, 530 mmol) and water (5.5 ml). The reaction is stirred overnight at RT, diluted with water (50 ml), and the brown slurry is filtered. The cake is dried overnight to afford 1.86 g (94%) of methyl 2-formyl-1-benzofuran-6-carboxylate as an amber solid. 1H NMR (400 MHz, DMSO-d6): δ 3.91, 8.03, 8.28, 9.92 ppm.

후처리

  1. filtrationthe brown slurry is filtered
  2. customThe cake is dried overnight

출처 및 근거

ORD 기록
ord-4dad4694ab0d4afaaea41f686a14aabe
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06894042B2

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