Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 218169생성일: 2026년 10월 26일
Bromocycloheptane → methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate
https://huagongshe.com/reaction/218169
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Bromocycloheptane | HCID 16992 | — |
| 반응물 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 반응물 | methyl 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate | HCID 59251051 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate | HCID 68702551 | 60% |
반응 단계
Methyl 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate (500 mg, 1.62 mmol, prepared in Synthetic Intermediate III(c)) was dissolved in 5 mL DMSO and NaHMDS (2.4 mL, 2.4 mmol, 1.0 M in THF) was added followed by bromocycloheptane (446 uL, 3.25 mmol). The reaction was heated overnight at 85° C. The reaction was quenched with TFA and purified by HPLC to give methyl 3-(1-cycloheptyl-1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoate (393 mg, 60%). (M+H)+=405.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08198311B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_06 |
|---|
| ORD ID | ord-60fecc13f5284888bf25953c32ff45cc |
|---|
| 출처 메모 | uspto-grants-2012_06 |
|---|
