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Trifluoroacetic acid → N-(3-Chloro-benzyl)-N-(3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)-acetamide

HRID 2182176
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HRID 2182176 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[N:18][CH:17]=[C:16]([N:20]([C:29](=[O:31])[CH3:30])[CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O.C([O-])(O)=O.[Na+]>C(Cl)Cl>[Cl:28][C:24]1[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=1)[CH2:21][N:20]([C:16]1[N:15]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:19]=[N:18][CH:17]=1)[C:29](=[O:31])[CH3:30]
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참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 697323276'-[Acetyl-(3-chloro-benzyl)-amino]-2,3,5,6-tetra-hydro-[1,2']bipyrazinyl-4-carboxylic acid tert-butyl ester

생성물 1

HCID 9924306N-(3-Chloro-benzyl)-N-(3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-6'-yl)-acetamide수율 126.3%

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

To a solution of 6′-[acetyl-(3-chloro-benzyl)-amino]-2,3,5,6-tetrahydro-[1,2′]bipyrazinyl-4-carboxylic acid tert-butyl ester I-5c (27.1 mg, 0.06 mmol) in methylene chloride (1 mL) was added trifluoroacetic Acid (1 mL). The reaction mixture was stirred at room temperature until the reaction was completed. The reaction mixture was poured into saturated NaHCO3 (20 mL) and extracted with methylene chloride (2×15 mL). The organic layers were combined, dried (Na2SO4), filtered, and concentrated to dryness to yield the title compound 5-A (26.2 mg).

후처리

  1. extractionextracted with methylene chloride (2×15 mL)
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-5ac56bed6b7b4a07b2e8365089018aea
출처 데이터셋
uspto-grants-2005_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06894050B2

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