참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 1-(Pyridin-3-yl)-4-tert-butoxycarbonylhomopiperazine | HCID 10802494 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Tert-butyl 4-(6-bromopyridin-3-yl)-1,4-diazepane-1-carboxylate | HCID 22478562 | — |
반응 단계
1-(3-Pyridyl)-4-tert-butoxycarbonyl homopiperazine (25.0 g, 90.1 mmol) was solved in acetonitrile (400 ml) and cooled to 0° C. N-Bromosuccinimide (19.3 g, 108.2 mmol) was added during 10 min. Water (400 ml) was added and the mixture was extracted twice with diethyl ether (200 ml). Chromatography on silica gel with a mixture of petroleum: ethyl acetate (1:1) gave the title compound as free base. Yield 18.7 g, 58%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06897219B2 |
|---|
| 출처 데이터셋 | uspto-grants-2005_05 |
|---|
| ORD ID | ord-ef958457bc004d1daadb6440c6752247 |
|---|
| 출처 메모 | uspto-grants-2005_05 |
|---|
