Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-chloro-phenyl)-{4-[hydroxy-(1-trityl-1H-imidazol-4-yl)-methyl]-1-methyl-1H-pyrrol-2-yl}methanone → (4-chlorophenyl)-[1-methyl-4-(1-trityl-1H-imidazole-4-carbonyl)-1H-pyrrol-2-yl]methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-chloro-phenyl)-{4-[hydroxy-(1-trityl-1H-imidazol-4-yl)-methyl]-1-methyl-1H-pyrrol-2-yl}methanone | HCID 22481044 | — |
| 촉매 | HCID 178418406 | HCID 178418406 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (4-chlorophenyl)-[1-methyl-4-(1-trityl-1H-imidazole-4-carbonyl)-1H-pyrrol-2-yl]methanone | HCID 22481054 | 91.2% |
반응 단계
A solution 2.2 g of (4-chloro-phenyl)-{4-[hydroxy-(1-trityl-1H-imidazol-4-yl)-methyl]-1-methyl-1H-pyrrol-2-yl}methanone in 50 mL of CH2Cl2 was stirred with 2.5 g of activated manganese dioxide overnight. The reaction was filtered and the filtrate was evaporated in vacuo to give 2.0 g of (4-chlorophenyl)-[1-methyl-4-(1-trityl-1H-imidazole-4-carbonyl)-1H-pyrrol-2yl]methanone. CI-MS m/z=556 (M++H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06897319B2 |
| 출처 데이터셋 | uspto-grants-2005_05 |
| ORD ID | ord-ee6f703721df4b17a9b06c3a10cdb866 |
| 출처 메모 | uspto-grants-2005_05 |