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Sodium Bicarbonate → 6-[2-(4-{2-[3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}phenoxy)acetylamino]hexanoic Acid

HRID 2182857
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HRID 2182857 반응식
[N+](C1C=C(S(CC[O:15][C:16](=[O:61])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:60])[CH2:24][O:25][C:26]2[CH:31]=[CH:30][C:29]([S:32]([N:35]3[C:39]4[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=4[N:37]=[C:36]3[S:44]([CH2:46][C:47]3[C:52]([CH3:53])=[C:51]([O:54][CH2:55][C:56]([F:59])([F:58])[F:57])[CH:50]=[CH:49][N:48]=3)=[O:45])(=[O:34])=[O:33])=[CH:28][CH:27]=2)(=O)=O)C=CC=1)([O-])=O.C([O-])(O)=O.[Na+]>CC#N.O.CC(O)C>[CH3:53][C:52]1[C:47]([CH2:46][S:44]([C:36]2[N:35]([S:32]([C:29]3[CH:28]=[CH:27][C:26]([O:25][CH2:24][C:23]([NH:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][C:16]([OH:61])=[O:15])=[O:60])=[CH:31][CH:30]=3)(=[O:34])=[O:33])[C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][C:38]=3[N:37]=2)=[O:45])=[N:48][CH:49]=[CH:50][C:51]=1[O:54][CH2:55][C:56]([F:58])([F:57])[F:59]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 207863756-[2-(4-{2-[3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}-phenoxy)acetylamino]hexanoic acid 2-(3-nitrobenzenesulfonyl)ethyl ester2회

생성물 1

HCID 224793036-[2-(4-{2-[3-Methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}phenoxy)acetylamino]hexanoic Acid수율 43.1%

시약·촉매·용매 1

HCID 22159075
CH3CN-H2O iPrOH
용매

실험 절차

A solution of 6-[2-(4-{2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}-phenoxy)acetylamino]hexanoic acid 2-(3-nitro-benzenesulfonyl)ethyl ester (Intermediate 20, 450 mg, 0.50 mmol) and of NaHCO3 (50 mg, 0.60 mmol, 1.2 eq) in CH3CN-H2O-iPrOH (2 mL:1 mL:1 mL) was heated to 70° C. for 1.5 h. Thereafter volatile materials were removed by evaporation, the residual gummy oil was dissolved in CH2Cl2, and the mixture was filtered to remove undissolved solid. The filtrate was dried and concentrated under reduced pressure. The residual oil was purified by silica gel column to yield 150 mg of Compound 7 as a light brown foam.

후처리

  1. customThereafter volatile materials were removed by evaporation
  2. dissolutionthe residual gummy oil was dissolved in CH2Cl2
  3. filtrationthe mixture was filtered
  4. customto remove undissolved solid
  5. customThe filtrate was dried
  6. concentrationconcentrated under reduced pressure
  7. customThe residual oil was purified by silica gel column

출처 및 근거

ORD 기록
ord-631870ad0585409d8c3f4e6ea9f94fdd
출처 데이터셋
uspto-grants-2005_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06897227B2

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