Dichloromethane → [(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER

HRID 2183446노트

반응식

HRID 2183446 반응식
[C:1]([NH:8][C@H:9]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:10][N:11]=[N+]=[N-])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].C(Cl)Cl.CCOC(C)=O.C(N(CC)CC)C>CO.C1COCC1>[C:1]([NH:8][C@H:9]([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[CH2:10][NH2:11])([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2]

참가 물질

7

반응물 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 20790081(R)-2-(Boc-amino)-2-phenylethylazide

생성물 1

HCID 15675183[(1R)-2-AMINO-1-PHENYLETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER수율 82%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

Using a similar hydrogenolysis procedure to that described as Deprotection Method A, (R)-2-(Boc-amino)-2-phenylethylazide (32.5 g, 124 mmol) in methanol (200 mL) and THF (300 mL) afforded, after chromatography (SiO2, 10:5:1 CH2Cl2, EtOAc, triethylamine), 24.0 g (82%) of the title compound

후처리

  1. customafforded

출처 및 근거

ORD 기록
ord-1fe9d4a7c8ac476c84427cab5e4657d5
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900196B2

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