Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Aminopyridine → (S)-[3-(1-amino-ethyl)-phenyl]-pyridin-4-yl-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Aminopyridine | HCID 1727 | — |
| 반응물 | Potassium Phosphate, Tribasic | HCID 62657 | — |
| 반응물 | (S)-N-Boc-1-(3-bromophenyl)ethylamine | HCID 56971804 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | (S)-[3-(1-amino-ethyl)-phenyl]-pyridin-4-yl-amine | HCID 60004117 | 103.2% |
반응 단계
A mixture of (S)-[1-(3-bromo-phenyl)-ethyl]-carbamic acid tert-butyl ester (3 g), 4-aminopyridine (1.88 g), Pd2(dba)3 (915 mg), di-t-butylbiphenylphosphine (298 mg), K3PO4 (4.24 g) in DME (20 mL) was stirred under reflux for 24 h. The reaction mixture was cooled down to room temperature, diluted with methylene chloride, filtered and concentrated in vacuo. The resulting residue was purified by flash chromatography using Biotage eluting with 5% MeOH in ethyl acetate to give the desired product (2.2 g) as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06900210B2 |
| 출처 데이터셋 | uspto-grants-2005_05 |
| ORD ID | ord-73a443b1df5f4abd86a7984885efeef0 |
| 출처 메모 | uspto-grants-2005_05 |