Triethylamine → 3-(2,5-Difluoro-phenyl)-N-{1-[3-(pyridin-4-ylamino)-phenyl]ethyl}-acrylamide

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
반응물	(S)-[3-(1-amino-ethyl)-phenyl]-pyridin-4-yl-amine	HCID 60004117	—
반응물	2.5-Difluoro-chlorocinnamic acid	HCID 86759747	—
촉매	4-(Dimethylamino)pyridine	HCID 14284	—
용매	Dichloromethane	HCID 6344	—
생성물	3-(2,5-Difluoro-phenyl)-N-{1-[3-(pyridin-4-ylamino)-phenyl]ethyl}-acrylamide	HCID 69800304	81.7%

반응 단계

A mixture of (S)-[3-(1-amino-ethyl)-phenyl]-pyridin-4-yl-amine (0.1 mmol), 2.5-difluoro-chlorocinnamic acid (0.1 mmol), EDAC.HCl (0.2 mmol), DMAP (0.1 mmol), triethylamine (0.3 mmol) in dichloromethane (2 mL) was stirred at room temperature overnight. The reaction mixture was purified by flash chromatography with 5% methnol in ethyl acetate to provide the title compound (31 mg) as a solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06900210B2
출처 데이터셋	uspto-grants-2005_05
ORD ID	ord-516a3a37db3a4d388f037877ad273a50
출처 메모	uspto-grants-2005_05