Ethanol → 3-(Benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride

HRID 2183592

반응식

HRID 2183592 반응식
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([C:10](=O)[CH2:11][Cl:12])=[CH:7][CH:8]=[CH:9][C:2]1=2.[NH:14]1[CH2:18][CH2:17][NH:16][C:15]1=[S:19].C(O)C>C(O)(=O)C>[ClH:12].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([C:10]3[N:16]4[CH2:17][CH2:18][N:14]=[C:15]4[S:19][CH:11]=3)=[CH:7][CH:8]=[CH:9][C:2]1=2

참가 물질

5

반응물 3

HCID 702EthanolHCID 2723650EthylenethioureaHCID 224737991-(Benzo[b]thiophen-4-yl)-2-chloroethan-1-one

생성물 1

HCID 224738373-(Benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride수율 107.5%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 1-(benzo[b]thiophen-4-yl)-2-chloroethan-1-one (1.15 g), 2-imidazolidinethione (0.57 g), ethanol (10 ml) and acetic acid (6 ml) was heated under reflux for 18 hours then cooled to ambient temperature. The solvents were removed in vacuo and the residue was triturated with ether (30 ml). The resulting solid was collected by filtration, washed with ether (30 ml) and dried in vacuo at 40° C. to give 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride (1.73 g) as a cream solid, m.p. 246-249° C.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. customThe solvents were removed in vacuo
  4. customthe residue was triturated with ether (30 ml)
  5. filtrationThe resulting solid was collected by filtration
  6. washwashed with ether (30 ml)
  7. customdried in vacuo at 40° C.

출처 및 근거

ORD 기록
ord-5817eaaee1a84fc79c01a652dd385234
출처 데이터셋
uspto-grants-2005_05
특허 번호
US06900216B2

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